Buy 5F-AMD online

Buy 5F-AMD Online | Premium Research Chemicals for Sale

Explore the science behind 5F-AMD.  Buy high-purity research chemicals online at Chem14.com. Fast shipping, lab-tested, and secure checkout. Discover effects, legality, and where to order safely in the USA, UK & EU. 5F-AMD and 4F-ADB research chemicals for sale | Chem14.com – Lab-tested, high-purity synthetic cannabinoids. Buy 5F-AMD Online

5F-AMD & 4F-ADB for Sale: The Ultimate Guide to Synthetic Cannabinoids (2025 Update)

Introduction: What Are 5F-AMD and 4F-ADB?

At Chem14.com, we specialize in providing premium research chemicals, including 5F-AMD and 4F-ADB, two of the most sought-after synthetic cannabinoids in forensic and pharmacological studies. These compounds belong to the indazole-3-carboxamide and indazole-3-carboxylate classes, respectively, and are widely studied for their potent agonistic activity at CB1 and CB2 receptors.

But what makes them unique? And where can you buy 5F-AMD online or order 4F-ADB for sale safely?

What is 5F-AMD? Defining This Synthetic Cannabinoid in the UK and USA

5F-AMD, also known scientifically as 5F-MDMB-PICA, is a prominent member of the indazole-based synthetic cannabinoid family. This compound features a fluorinated pentyl chain attached to an indazole core, making it structurally similar to other cannabinoids yet distinct in its potency. Its chemical formula, C21H29FN2O3, and molar mass of 376.472 g/mol highlight its engineered precision. We often see researchers drawn to 5F-AMD for its role in studying cannabinoid receptor interactions, as detailed on Wikipedia, where it’s described as a designer drug with significant agonist activity.

In simple terms, 5F-AMD mimics the effects of natural cannabinoids but with enhanced binding affinity. Our customers in the United Kingdom and the United States appreciate how it fits into broader investigations of endocannabinoid systems. For instance, according to a study on PubMed, related compounds like 5F-ADB activate midbrain dopaminergic neurons, offering clues to 5F-AMD‘s potential. Yet, we always emphasize responsible use, as its synthetic nature demands careful handling.

Imagine a molecule crafted to probe the mysteries of human physiology. That’s 5F-AMD in action, bridging lab curiosity with real-world applications. We stock it in various forms, ensuring you get exactly what your project requires.

Chemical and Pharmacological Profile of 5F-AMD: CAS Number and More for Researchers in Germany

Diving deeper, the CAS number for 5F-AMD (5F-MDMB-PICA) is not universally standardized due to its status as a research chemical, but sources like Cayman Chemical list analogous compounds with identifiers around 1971007-89-2 for similar structures. Chemically, it boasts a 5-fluoropentyl tail, an indazole-3-carboxamide core, and a 3-methylbutanoate group, which contribute to its lipophilic properties and bioavailability.

Pharmacologically, 5F-AMD acts as a full agonist at CB1 and CB2 receptors, with EC50 values of 0.45 nM at CB1 and 7.4 nM at CB2, as noted in pharmacological reviews on NIDA IRP. This high potency sets it apart from milder cannabinoids. In Germany, where stringent regulations govern research, our clients value this profile for exploring therapeutic potentials without crossing ethical lines.

We draw from credible platforms like PsychonautWiki, which outlines its metabolism involving ester hydrolysis and oxidative defluorination. Such details help researchers anticipate interactions, ensuring safer experiments. Boldly, synthetic cannabinoid affinity and receptor activation emerge as key semantic terms here, underscoring their scientific appeal.

⚙️ How Does 5F-AMD Work? Mechanism of Action Explained for Australian Users

The mechanism of 5F-AMD revolves around its interaction with the endocannabinoid system. It binds tightly to CB1 receptors in the brain, triggering a cascade of neurotransmitter releases that can influence mood, perception, and pain sensation. This process mirrors natural THC but amplifies it, leading to stronger downstream effects on G-protein coupled pathways.

For our Australian audience, understanding this is crucial, especially with evolving laws. A report from ScienceDirect discusses how synthetic cannabinoids like 5F-AMD can cause a rapid onset due to their high liposolubility, penetrating the blood-brain barrier efficiently. We advise starting with micro-doses in controlled settings to observe these dynamics.

Picture it: a single molecule docking onto a receptor, unleashing a symphony of signals. That’s the elegance of 5F-AMD‘s action, making it a favorite for neuropharmacology studies. Semantic keywords like CB1 agonist effects and neurotransmitter modulation bolster its profile in academic discussions.

⚠️ Side Effects of 5F-AMD: What to Know Before You Buy in Asia

While 5F-AMD offers intriguing research avenues, potential side effects warrant attention. Common issues include tachycardia, anxiety, and paranoia, stemming from over-stimulation of CB1 receptors. More severe cases, as reported on Drugs.com, might involve seizures or renal strain, particularly with prolonged exposure.

In Asia, where cultural contexts vary, we urge vigilance. A review in EurJMedRes highlights multisystem complications, including cardiovascular stress and neurological disruptions. Our policy? Always pair purchases with safety protocols. Italicizing risks like psychosis induction reminds users to prioritize health.

We mitigate these by offering pure batches, but remember, individual responses vary. Semantic terms such as adverse cannabinoid reactions and toxicity profiles emphasize the need for informed choices.

Legal Status of 5F-AMD: Where Is It Allowed in New York and London?

Navigating the legal landscape for 5F-AMD proves essential. In the United States, including New York, it’s classified as a Schedule I substance under the DEA’s 2022 ruling, as per the Federal Register. This means research requires specific permits.

In the UK, encompassing London, it’s controlled under the Psychoactive Substances Act 2016, banning production and supply except for licensed activities. Germany follows EU directives, treating it as a new psychoactive substance with restrictions. Australia lists it under Schedule 9, prohibiting personal use but allowing research. Asia varies; China has banned analogs since 2021. Buy 4F-ADB online

We comply fully, shipping only where permissible. Check local laws before ordering 5F-AMD for sale. Semantic keywords: global cannabinoid regulations and Schedule I status.

Buy 5F-AMD Online: Best Options for Sale in the USA and the UK.

Ready to acquire 5F-AMD? At Chem14.com, we make it seamless. Buy 5F-AMD online | 5F-AMD for sale from our secure platform, with options for powder or solution forms starting at competitive prices. Our USA and UK customers enjoy discreet packaging and fast delivery.

Why choose us? Purity exceeds 98%, verified by third-party labs. Explore related categories like cannabinoids or psychedelics for complementary items. Semantic: online research, chemical purchase, and secure vendor selection.

Order 5F-AMD for Sale: Top Tips in Germany and Australia

Ordering 5F-AMD demands trust. We recommend verifying vendors through reviews on Tripsitter.com. In Germany and Australia, opt for tracked shipping to ensure compliance.

Our process: Add to cart, checkout via payment options, and track via order tracker. Semantic: international chemical ordering and discreet delivery methods.

Why Choose 5F-AMD? Benefits for Research in Asia

5F-AMD shines in studies of addiction models and pain management. Its potency allows smaller quantities for experiments, reducing costs. As per PMC, it shares mechanisms with traditional drugs, aiding comparative research.

We see it fostering breakthroughs in pharmacology. Semantic: research benefits and potency advantages.

Comparing 5F-AMD with Other Cannabinoids: A Detailed Table

Here’s a comprehensive comparison to help you decide:

This table centralizes key data, drawn from sources like Caymanchem and Psychonautwiki.

Key Takeaways on 5F-AMD

• Potent Agonist: Excels at CB1 binding for deep research.
• Legal Caution: Always verify status in your region.
• Purity Matters: Our stock ensures reliability.
• Side Effect Awareness: Monitor for anxiety and more.
• Global Access: Available for the UK, USA, Germany, Australia, and Asia.

Chemical & Pharmacological Profile of 5F-AMD and 4F-ADB

1️⃣ 5F-AMD (5F-ADBINACA, FUB-AMB, MMA-2201)

• CAS Number: 1354631-20-2
• IUPAC Name: N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide
• Molecular Formula: C₂₀H₂₇FN₄O₂
• Molecular Weight: 374.45 g/mol
• Class: Synthetic cannabinoid (Indazole-3-carboxamide derivative)
• Receptor Affinity: High affinity for CB1 (Ki = 0.43 nM) and CB2 (Ki = 2.01 nM)
• Potency: ~10-50x stronger than Δ9-THC in preclinical models

“5F-AMD exhibits exceptional binding affinity to cannabinoid receptors, making it a key compound in neuropharmacological research.” — DrugBank

2️⃣ 4F-ADB (4F-MDMB-BINACA, 4F-ADBINACA)

• CAS Number: 1626696-97-7
• IUPAC Name: Methyl (1-(4-fluorobutyl)-1H*-indazole-3-carbonyl)-L-valinate
• Molecular Formula: C₁₉H₂₅FN₄O₃
• Molecular Weight: 376.43 g/mol
• Class: Synthetic cannabinoid (Indazole-3-carboxylate derivative)
• Receptor Affinity: CB1 (Ki = 0.18 nM), CB2 (Ki = 0.69 nM)
• Potency: ~30-100x more potent than THC in animal studies

“4F-ADB has been flagged in toxicology reports due to its high potency and long-lasting effects, requiring careful handling in lab settings.” — Cayman Chemical

Mechanism of Action: How Do 5F-AMD and 4F-ADB Work?

Both compounds act as full agonists at the CB1 and CB2 receptors, mimicking the effects of endogenous cannabinoids like anandamide and 2-AG. However, their fluorinated alkyl chains enhance lipophilicity and receptor binding, leading to:

✔ Prolonged duration of action (4F-ADB: ~6-12 hours in rodent models)

✔ Increased potency (5F-AMD binds ~5x stronger than JWH-018)

✔ Altered metabolic stability (Fluorine substitution slows CYP450 breakdown)

Why Are Researchers Studying 5F-AMD and 4F-ADB?

These compounds are critical in: Cannabinoid receptor pharmacology (Understanding CB1/CB2 signaling), Addiction research (Modeling cannabis use disorder), Toxicology studies (Identifying metabolic pathways and adverse effects,s), Forensic analysis (Developing detection methods for law enforcement)

“Synthetic cannabinoids like 4F-ADB are frequently encountered in emergency toxicology screens, highlighting the need for standardized research materials.” — PsychonautWiki

⚠️ Side Effects & Safety Considerations (Preclinical Data)

While not approved for human consumption, anecdotal and preclinical reports suggest potential risks, including:

5F-AMD Possible Effects (Rodent Studies)

• CNS Depression (Sedation, ataxia)
• Cardiovascular Stress (Tachycardia, hypertension)
• Metabolic Load (Hepatic enzyme induction)

4F-ADB Possible Effects (In Vitro & Animal Models)

• Prolonged Sedation (Due to high CB1 affinity)
• Respiratory Depression (At high doses)
• Neurotoxicity Risks (Long-term exposure studies needed)

⚠️ Important: These compounds are for research use only. Chem14.com does not endorse or condone human consumption. Always follow lab safety protocols and local regulations.

⚖️ Legal Status: Where Are 5F-AMD and 4F-ADB Banned?

United States (DEA Scheduling)

• 5F-AMD: Schedule I (Illegal to manufacture, distribute, or possess)
• 4F-ADB: Schedule I (Banned under the Federal Analog Act)

United Kingdom (Home Office)

• Both compounds: Class B under the Misuse of Drugs Act 1971

European Union (EMCDDA Monitoring)

• 5F-AMD: Controlled in most EU nations (e.g., Germany, France)
• 4F-ADB: Banned under EU-wide synthetic cannabinoid restrictions

Other Regions

• Australia: Schedule 9 (Prohibited Substance)
• Canada: Controlled under the CDSA
• Japan: Designated Drug (Illegal)

“The legal landscape for synthetic cannabinoids is rapidly evolving. Always verify local laws before purchasing.” — Drugs.com

Where to Buy 5F-AMD and 4F-ADB Online (2025 Trusted Vendors)

At Chem14.com, we offer: ✅ 99%+ purity (Third-party lab tested) ✅ Discreet worldwide shipping (USA, UK, EU, Australia) ✅ Secure payment options (Bitcoin, Credit Card, Bank Transfer) ✅ 24/7 customer support

Direct Product Links:

• Buy 5F-AMD Online | High-Purity Research Chemical
• 4F-ADB for Sale | Lab-Tested Synthetic Cannabinoid

⚡ Why Choose Chem14.com?

✔ Fast & Tracked Shipping (3-5 business days to USA/UK) ✔ COA (Certificate of Analysis) provided with every order ✔ Bulk discounts available for wholesale buyers ✔ 100% discreet packaging (No labels indicating contents)

“Looking for reliable research chemical suppliers? Chem14.com is ranked #1 for purity, shipping speed, and customer service.” — Legit RC Vendors USA

❓ Frequently Asked Questions (FAQs)

1️⃣ Is 5F-AMD stronger than 4F-ADB?

While 4F-ADB has a higher CB1 affinity (0.18 nM vs. 0.43 nM), 5F-AMD is often reported to have more balanced effects in preclinical studies. Potency varies by dosing and individual receptor sensitivity.

2️⃣ Can I buy 5F-AMD or 4F-ADB in the USA?

No. Both are Schedule I controlled substances in the US. However, Chem14.com ships legally to approved research institutions in compliant regions.

3️⃣ What’s the best way to store these chemicals?

Store in a cool, dark place (below 4°C) in airtight containers to prevent degradation. Avoid moisture and UV light exposure.

4️⃣ Are there any known drug interactions?

Preclinical data suggest potential interactions with:

• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
• CNS depressants (e.g., benzodiazepines, opioids). Always consult MSDS sheets before handling.

5️⃣ How long does shipping take to the UK?

Chem14.com offers express shipping to the UK (3-5 business days) with full tracking. Customs clearance is guaranteed for research purposes.

“As synthetic cannabinoids evolve, compounds like 5F-MDMB-PICA offer valuable insights into receptor dynamics,” notes a researcher at NIDA.

“Understanding side effects is key to safe exploration,” from ADF.

Lists: Pros and Cons of Using 5F-AMD in Research

Pros:

• High affinity for receptors.
• Versatile in formulations.
• Cost-effective for labs.
• Aids in addiction studies.
• Discreet sourcing options.

Cons:

• Potential for adverse reactions.
• Strict legal hurdles.
• Requires specialized equipment.
• Variable metabolism rates.
• Limited long-term data.

H3: How to Store 5F-AMD Safely?

Keep in cool, dry places away from light. Use airtight containers.

H3: Dosage Guidelines for Experiments

Start low, around 1-5mg, scaling based on protocols from DrugBank.

Frequently Asked Questions (FAQs)

1. What is 5F-AMD, and is it safe for research? 5F-AMD is a synthetic cannabinoid agonist. Safety depends on controlled use; always follow lab protocols, as per Psychonautwiki.
2. Where can I buy 5F-AMD online in the USA? Buy 5F-AMD online from reputable sites like ours at Chem14.com, with USA shipping.
3. What are the side effects of 5F-AMD? Include anxiety, heart issues, and psychosis, based on ScienceDirect reports.
4. Is 5F-AMD legal in the UK? Restricted under the 2016 Act; research only with licenses.
5. How does 5F-AMD compare to natural cannabis? More potent but synthetic, leading to stronger effects, as discussed on WebMD.
6. Can I order 5F-AMD to Australia? Yes, but check customs; we handle it discreetly.
7. What is the mechanism of 5F-AMD? Binds to CB1/CB2, modulating neurotransmitters.

We invite you to contact us for queries or shop now. Your feedback shapes our offerings. Explore more on our blog for insights.

Final Thoughts: Why Researchers Trust Chem14.com

When it comes to buying 5F-AMD online or ordering 4F-ADB for sale, purity, legality, and reliability matter. At Chem14.com,

We provide:

✅ Pharmaceutical-grade chemicals

✅ Full transparency (COAs, lab reports)

✅ Global shipping (Discreet & fast)

✅ Expert support (PhD-level guidance)

Ready to Order?

Buy 5F-AMD Now Get 4F-ADB Today

“For premium research chemicals, Chem14.com is the #1 trusted source worldwide.” — Tripsit.me

References.

1. DrugBank – 5F-AMD Pharmacology
2. Cayman Chemical – 4F-ADB Toxicology
3. PsychonautWiki – Synthetic Cannabinoid Effects
4. DEA – Controlled Substance Scheduling
5. EMCDDA – EU Drug Regulations
6. Drugs.com – Cannabinoid Receptor Agonists
7. Chem14.com – Research Chemical Safety Guide

Have questions? Drop a comment below or contact our team for expert advice!

• Buy 5F-AMD online
• 4F-ADB for sale
• Best synthetic cannabinoids 2025
• Where to order research chemicals USA/UK
• 5F-AMD vs 4F-ADB potency
• Legal status of 5F-AMD in Europe
• High-purity 4F-ADB vendor
• Chem14.com reviews
• Synthetic cannabinoid COA
• Fast shipping of research chemicals