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What is bromonordiazepam?

Bromonordiazepam is a benzodiazepine derivative with CAS number 2894-61-3 used exclusively for research purposesBromonordiazepam, also known as desalkylgidazepam, is a benzodiazepine compound that has gained attention in the research chemical community. Structurally similar to diazepam and nordazepam, it features a bromine substitution at position 7, distinguishing it from its chloro-substituted counterparts.

Originally identified as the active metabolite of gidazepam (a drug licensed in Ukraine and Russia), bromonordiazepam has emerged independently in the designer drug market. According to Wikipedia, its in vitro potency is comparable to alprazolam’s, though subjective effects remain under-documented.

 

How does bromonordiazepam work?

Bromonordiazepam works by modulating GABA_A receptors in the central nervous system, producing calming effectsLike other benzodiazepines, bromonordiazepam exerts its pharmacological effects through positive allosteric modulation of the GABA_A receptor. This mechanism of action enhances the inhibitory effects of the neurotransmitter gamma-aminobutyric acid (GABA), resulting in central nervous system depression.

The Cayman Chemical profile confirms that desalkylgidazepam (the systematic name for bromonordiazepam) binds to the benzodiazepine site on the GABA_A receptor complex, producing the following:

• Anxiolytic effects (reduced anxiety)
• Sedative effects (promoting relaxation)
• Muscle relaxant properties
• Anticonvulsant activity

This mechanism is consistent with other benzodiazepine compounds, though bromonordiazepam may exhibit unique pharmacokinetic properties due to its bromine substitution. Researchers studying GABAergic systems find Bromonordiazepam particularly valuable for investigating receptor subtype selectivity and binding affinities.

For those looking to buy bromonordiazepam online, understanding this mechanism of action helps contextualise its potential applications in neuroscience research and drug development.

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Buy Bromonordiazepam pellets online at Chem14.com with fast, discrete shipping to the UK, USA, Germany and AustraliaWhen searching for bromonordiazepam for sale, researchers must prioritise quality, purity, and reliability. Chem14.com stands as a trusted supplier of high-purity research chemicals, including Bromonordiazepam pellets with CAS 2894-61-3.

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Bromonordiazepam: chemical and pharmacological profile

Bromonordiazepam’s chemical profile includes CAS 2894-61-3, molecular formula C₁₅H₁₁BrN₂O and long-lasting anxiolytic effects

Chemical Structure and Properties

Bromonordiazepam possesses a benzodiazepine core structure with the following characteristics:

• IUPAC Name: 7-bromo-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
• CAS Number: 2894-61-3
• Molecular Formula: C₁₅H₁₁BrN₂O
• Molecular Weight: 315.2 g/mol
• SMILES: O=C1NC2=CC=C(C=C2C(C3=CC=CC=C3)=NC1)Br
• InChI Key: ATCCWKYKHCKDGT-UHFFFAOYSA-N

The ChemicalBook entry confirms that Bromonordiazepam is closely related to diazepam in structure but features a bromine atom at the 7-position instead of chlorine. This structural modification influences its pharmacological profile and metabolic pathway.

Pharmacological Characteristics

As a benzodiazepine derivative, bromonordiazepam exhibits the following:

• High affinity for GABA_A receptors
• Long duration of action due to extended half-life
• Anxiolytic potency comparable to alprazolam in in-vitro studies
• Sedative effects that develop within 20 minutes to 1 hour of administration
• Low non-therapeutic potential according to ChemicalBook

The pharmacological profile of bromonordiazepam makes it particularly interesting for researchers investigating the following:

• Benzodiazepine receptor subtype selectivity
• Metabolism pathways of designer benzodiazepines
• Comparative pharmacology between brominated and chlorinated benzodiazepines
• Toxicity profiles of novel psychoactive substances

For comprehensive pharmacological data, researchers can reference the ResearchGate publication on designer benzodiazepines gidazepam and desalkygidazepam (bromonordiazepam).

What are the effects of Bromonordiazepam?

Bromonordiazepam produces anxiolytic, sedative, muscle relaxant and anticonvulsant effects through GABAergic modulationBased on its benzodiazepine classification and GABA_A receptor modulation, bromonordiazepam is expected to produce the following primary effects:

Primary Therapeutic Effects

• Anxiolysis: Reduction of anxiety and stress responses
• Sedation: Promotion of relaxation and calmness
• Muscle Relaxation: Decrease in muscle tension and spasticity
• Anticonvulsant Activity: Suppression of seizure activity
• Hypnotic Effects: Induction of sleep at higher doses

Subjective Effects

While subjective reports on bromonordiazepam remain limited compared to more established benzodiazepines, researchers and PsychonautWiki contributors describe the following:

• Cognitive relaxation and anxiety reduction
• Physical relaxation and muscle heaviness
• Mild euphoria at therapeutic doses
• Sedation that increases with dosage
• Memory impairment at higher doses (though reportedly less pronounced than with some other benzodiazepines)

The onset of effects typically occurs within 20 minutes to 1 hour, with the duration being exceptionally long due to the compound’s extended half-life. This pharmacokinetic profile makes bromonordiazepam particularly suitable for extended-duration studies and prolonged-effect investigations.

Important: The effects of Bromonordiazepam can vary significantly based on dosage, route of administration, individual metabolism, and concomitant substance use. Researchers should approach all studies with appropriate safety protocols and ethical considerations.

Bromonordiazepam side effects and safety considerations

Bromonordiazepam side effects may include drowsiness, dizziness, fatigue and potential dependence with prolonged useAs with all benzodiazepine compounds, bromonordiazepam carries potential side effects and safety concerns that researchers must consider:

Common Side Effects

• Drowsiness and sedation
• Dizziness and lightheadedness
• Fatigue and lethargy
• Cognitive impairment (memory, concentration)
• Motor coordination difficulties
• Headaches
• Gastrointestinal discomfort

Serious Side Effects

• Paradoxical reactions (agitation, aggression, anxiety)
• Respiratory depression (particularly when combined with other CNS depressants)
• Dependence and withdrawal symptoms with prolonged use
• Tolerance development requiring dose escalation
• Potential for overdose when mixed with alcohol, opioids, or other sedatives

Safety Guidelines for Research

When working with Bromonordiazepam pellets in a research setting, the following safety protocols are essential:

1. Use appropriate personal protective equipment (PPE)
2. Handle in a controlled laboratory environment
3. Avoid inhalation, ingestion, or skin contact
4. Store in a secure, temperature-controlled location
5. Dispose of waste according to hazardous material regulations
6. Maintain accurate records of all experimental procedures

Our research ethics and safety guidelines provide comprehensive information on safe handling of research chemicals.

Warning: Bromonordiazepam is not intended for human consumption. It is exclusively for research purposes. The side effects described are based on benzodiazepine class characteristics and limited available data. Always consult material safety data sheets (MSDS) and follow institutional safety protocols.

Is bromonordiazepam legal in the UK, the USA, Germany, and Australia?

Bromonordiazepam’s legal status varies by country but is not approved for human consumption in the UK, USA, Germany or AustraliaThe legal status of bromonordiazepam varies significantly across different jurisdictions. Researchers must verify the regulatory framework in their specific location before attempting to buy Bromonordiazepam online or conduct studies.

United Kingdom

In the UK, Bromonordiazepam falls under the Misuse of Drugs Act 1971 as a designer benzodiazepine. While not explicitly listed, it may be controlled as a structurally similar compound to scheduled substances. The WHO report indicates enhanced monitoring in the United Kingdom.

United States

In the USA, bromonordiazepam is not approved for human consumption by the FDA. As a designer drug, it may be subject to Drug Enforcement Administration (DEA) regulations under the Controlled Substances Act. The Garden State Treatment Center notes that similar benzodiazepines like bromazepam are not prescribed in the United States.

Germany

Germany’s Federal Narcotics Act (BtMG) includes numerous novel psychoactive substances (NPS). While Bromonordiazepam may not be explicitly listed, the UNODC database shows that Germany has been proactive in controlling designer benzodiazepines. Researchers should consult the BfArM (Federal Institute for Drugs and Medical Devices) for current status.

Australia

In Australia, bromonordiazepam would likely be considered a Schedule 9 substance (prohibited substance) under the Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP), similar to other non-approved benzodiazepines.

Asia and Other Regions

The legal status in Asian countries varies widely. Some nations may have strict controls on all benzodiazepines, while others may have no specific regulations for research chemicals. Researchers should consult local drug control agencies and customs regulations.

Important Legal Note: The legal status of research chemicals can change rapidly. Always verify current regulations with official government sources before attempting to order Bromonordiazepam pellets or any other research compound. Chem14.com complies with all applicable laws and regulations in the jurisdictions we serve.

Bromonordiazepam pellets dosage and administration for research

Bromonordiazepam dosage for research varies typically ranging from low to moderate microgram amounts in laboratory settingsWhen conducting research with bromonordiazepam pellets, determining appropriate dosage and administration methods is crucial for obtaining reliable, reproducible results.

Research Dosage Guidelines

While human dosage information is not applicable (as bromonordiazepam is not for human consumption), researchers working with animal models or in vitro systems typically consider the following:

• In-vitro studies: Nanomolar to micromolar concentrations
• Animal studies: Microgram to milligram per kilogram doses (varies by species)
• Pharmacokinetic studies: Tracer doses for metabolism and distribution analysis

Administration Methods in Research

• Oral administration (for pharmacokinetic studies)
• Intraperitoneal injection (for animal models)
• Intravenous injection (for acute effect studies)
• In-vitro receptor binding assays
• Cell culture studies

Important Considerations

1. Purity: Always use high-purity Bromonordiazepam pellets (≥98%) for accurate results
2. Solubility: Bromonordiazepam is soluble in DMSO, DMF, and ethanol (slightly soluble)
3. Stability: Store at -20°C for long-term stability
4. Metabolism: Consider hepatic metabolism in in-vivo studies
5. Interactions: Account for potential drug-drug interactions in combination studies

For detailed pharmacological data, researchers should consult the Cayman Chemical technical information and relevant scientific literature.

Reminder: All research involving Bromonordiazepam must be conducted in accordance with institutional review board (IRB) or animal care and use committee (IACUC) guidelines, as well as all applicable laws and regulations.

Bromonordiazepam vs other benzodiazepines

Bromonordiazepam differs from other benzodiazepines through its bromine substitution long half-life and unique metabolic profileWhen comparing Bromonordiazepam to other benzodiazepine compounds, several key differences emerge:

Feature	Bromonordiazepam	Diazepam	Alprazolam	Nordazepam
CAS Number	2894-61-3	439-14-5	28981-97-7	1088-11-5
Halogen	Bromine (Br)	Chlorine (Cl)	Chlorine (Cl)	None
Half-life	Very long	48-96 hours	6-26 hours	36-200 hours
Onset	20-60 minutes	15-60 minutes	15-30 minutes	30-60 minutes
Potency	Similar to alprazolam (in-vitro)	Moderate	High	Low-moderate
Metabolite of	Gidazepam	None	None	Diazepam
Primary Use	Research	Medical	Medical	Metabolite

Structural Comparison

Bromonordiazepam differs from diazepam primarily through the substitution of a bromine atom at the 7-position instead of chlorine. This structural modification affects:

• Receptor binding affinity
• Metabolic pathways
• Pharmacokinetic properties
• Duration of action

Pharmacological Comparison

Compared to alprazolam, bromonordiazepam exhibits the following:

• Similar in-vitro potency at GABA_A receptors
• Longer duration of action
• Different metabolic profile
• Potentially different receptor subtype selectivity

The Wikipedia entry notes that Bromonordiazepam is structurally similar to nordazepam but with bromine substitution, which may confer unique pharmacological properties.

For researchers interested in comparative benzodiazepine studies, our benzodiazepines for sale category offers a comprehensive selection of compounds for side-by-side analysis.

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What is the CAS number for bromonordiazepam?

The CAS number for Bromonordiazepam is 2894-61-3. This unique identifier is used to identify the compound in chemical databases and scientific literature precisely. Researchers can find detailed information using this CAS registry number on platforms like ChemicalBook and Cayman Chemical.

How does Bromonordiazepam compare to diazepam

Bromonordiazepam is structurally similar to diazepam but features a bromine atom at the 7-position instead of chlorine. This structural difference results in a longer half-life and potentially distinct receptor-binding characteristics. While both compounds are benzodiazepines that modulate GABA_A receptors, bromonordiazepam may offer unique pharmacological properties for research applications.

Where can I buy Bromonordiazepam pellets in the UK

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Is Bromonordiazepam legal in the USA

In the United States, bromonordiazepam is not approved for human consumption by the FDA. As a designer benzodiazepine, its legal status may be subject to DEA regulations. Researchers should verify current federal and state laws before attempting to order Bromonordiazepam pellets. Chem14.com complies with all applicable US regulations for research chemical sales.

What is the half-life of bromonordiazepam?

Bromonordiazepam has a very long half-life, which contributes to its extended duration of action. According to ChemicalBook, this long-lasting property makes it particularly suitable for prolonged effect studies and pharmacokinetic investigations.

How should Bromonordiazepam pellets be stored

Bromonordiazepam pellets should be stored at -20°C for long-term stability. The Cayman Chemical technical information recommends room temperature for short-term storage and freezing for extended periods. Always use airtight containers and protect from light and moisture.

Can Bromonordiazepam be detected in drug tests

As a benzodiazepine derivative, bromonordiazepam may be detected by comprehensive drug tests that screen for benzodiazepine metabolites. However, standard drug tests may not specifically identify bromonordiazepam unless they include targeted analysis for designer benzodiazepines. The WHO report discusses the analytical detection of novel benzodiazepines in forensic settings.

Key Takeaways on Bromonordiazepam Pellets

• Bromonordiazepam (CAS 2894-61-3) is a benzodiazepine derivative with anxiolytic and sedative properties
• It is the active metabolite of gidazepam and exhibits a very long half-life
• The mechanism of action involves modulation of GABA_A receptors
• Bromonordiazepam is not approved for human consumption and is intended exclusively for research purposes
• The legal status varies by country, with restrictions in UK, USA, Germany, and Australia
• Researchers can buy Bromonordiazepam pellets online from reputable suppliers like Chem14.com
• Proper storage at -20°C ensures long-term stability of the compound
• Safety protocols must be followed when handling Bromonordiazepam in laboratory settings
• Comparative studies with other benzodiazepines reveal unique pharmacological properties
• Chem14.com offers high-purity Bromonordiazepam pellets with fast shipping and reliable service

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