Buy Dechloroetizolam Online

Buy Dechloroetizolam Online

Dechloroetizolam is a thienotriazolodiazepine analogue of Etizolam, lacking a chlorine atom, researched for its sedative and anxiolytic properties via GABA_A potentiation.

Welcome to Chem14, your trusted source for high-purity research chemicals. As the landscape of psychoactive research expands, understanding the nuances of each analogue becomes critical. Today, we are examining Dechloroetizolam, a compound that sits at the intersection of thienodiazepine chemistry and modern pharmacological study. Our goal is to provide researchers with a factual, data-driven overview that supports rigorous scientific inquiry. We always recommend consulting authoritative sources like DrugBank for pharmacological data and PsychonautWiki for harm reduction information, though we synthesize that data here for you.

What Is Dechloroetizolam and How Is It Used in Research? 🔬

Dechloroetizolam is a research chemical and structural analogue of Etizolam, used primarily to study GABA_A receptor binding affinities and sedative-hypnotic effects in vitro.

Dechloroetizolam (sometimes referred to as Etizolam-2) is a structural derivative of the better-known thienodiazepine, Etizolam. The key modification is the removal of the chlorine atom from the phenyl ring, which significantly alters its pharmacodynamic profile . In research settings, it is utilized to understand the structure-activity relationships of benzodiazepine-like compounds. Unlike traditional benzodiazepines, which have a benzene ring, thienodiazepines contain a thiophene ring, and this compound belongs to the thienotriazolodiazepine class. Researchers often study it to compare its binding efficacy against other designer benzodiazepines to predict potential potency and toxicity .

Researchers in the United Kingdom, United States, Germany, and Australia frequently seek out high-purity analogues to map the GABA_A receptor system. It is crucial to remember that this substance is strictly for laboratory and forensic research and is not intended for human consumption.

What Is the CAS Number and Chemical Structure of Dechloroetizolam?

Dechloroetizolam (CAS 40054-73-7) has the IUPAC name 2-Ethyl-9-methyl-4-phenyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine.

For the analytical chemist, precise identification is paramount. The CAS number 40054-73-7 is the unique identifier for Dechloroetizolam . Its molecular formula is C17H16N4S, with a molecular weight of 308.4 g/mol . The structure is characterized by a triazolo ring fused to a thienodiazepine skeleton, which is a defining feature of this chemical class. The absence of the chlorine atom (hence “deschloro”) is the primary structural distinction from its parent compound, making it a critical subject for quantitative structure-activity relationship (QSAR) modelling .

🔬 Chemical and Pharmacological Profile of Dechloroetizolam
Dechloroetizolam carries the systematic name 2-ethyl-9-methyl-4-phenyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine and the molecular formula C17H16N4S. Its CAS number is 40054-73-7.

This thienodiazepine binds to benzodiazepine sites on GABA-A receptors, enhancing GABA efficiency and producing central nervous system inhibition. The compound shows rapid onset and a total duration of eight to ten hours in research observations.

We source our material directly from trusted manufacturers to guarantee consistency for every batch. Our customers in the USA and UK report excellent results in binding assays and metabolic studies thanks to this reliability.

⚙️ How Does Dechloroetizolam Work? Mechanism of Action Explained
Dechloroetizolam acts as a positive allosteric modulator at GABA-A receptors, increasing inhibitory neurotransmission in the brain. This leads to the characteristic depressant profile seen in thienodiazepine research.

The removal of the chlorine atom compared with etizolam results in approximately half the potency but roughly twice the duration of effects in laboratory models. Researchers use this profile to study structure-activity relationships within the thienodiazepine class.

📊 Key Properties Comparison Table

This table highlights why many laboratories prefer our Dechloroetizolam for extended observation windows.

How Does Dechloroetizolam Interact with the Central Nervous System? 🧠

It acts as a positive allosteric modulator of GABA_A receptors, increasing the frequency of chloride channel opening to enhance inhibitory neurotransmission.

The primary mechanism of action for Dechloroetizolam, like other compounds in its class, involves the GABA_A receptor. It binds to a specific site on the receptor complex (the benzodiazepine site) to potentiate the effects of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) . When GABA binds to its receptor, it typically opens a chloride channel, hyperpolarizing the neuron and making it less likely to fire. By modulating this receptor, Dechloroetizolam increases the affinity of GABA for the receptor, leading to more frequent chloride channel opening. This results in the characteristic sedative, anxiolytic, and muscle relaxant effects observed in animal models . Recent studies using QSAR modelling help predict the binding affinity of such designer benzodiazepines, with some newer analogues showing even greater predicted potency .

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❓ Which Research Applications Suit Dechloroetizolam Best?
Laboratories use this compound to study anxiolytic mechanisms, metabolic pathways, and receptor binding kinetics. Its longer duration compared with etizolam makes it ideal for time-course experiments.

Dechloroetizolam vs. Etizolam: What Are the Comparative Pharmacological Profiles? ⚖️

Compared to Etizolam, Dechloroetizolam lacks a chlorine atom, resulting in lower potency but a distinct metabolic and binding profile.

This is a common point of inquiry for researchers. While both are thienodiazepines, the removal of the chlorine atom in Dechloroetizolam significantly alters its pharmacology. According to available data and comparative studies:

This comparison highlights the diverse nature of designer benzodiazepines and underscores why Dechloroetizolam remains a compound of interest for understanding how minor structural changes can lead to significant differences in biological activity .

Where Can I Find Reliable Dechloroetizolam Powder for Sale Online? 🛒

High-purity Dechloroetizolam is available for research purposes exclusively through reputable chemical suppliers like Chem14.com, with stringent quality control.

When your laboratory requires a trusted supply chain, sourcing matters. You can buy Dechloroetizolam online from Chem14, where we prioritize purity and consistency. We cater to researchers across the globe, including those in New York, London, and Berlin, ensuring that every batch is accompanied by certificates of analysis. Navigating the market for research chemicals requires diligence. We recommend avoiding unverified vendors and instead relying on established suppliers who understand the importance of legit research chemical vendors. For related compounds, you might also explore our range of benzodiazepines or other research chemical products available in our shop.

Why Choose Chem14 for Your Dechloroetizolam Research Needs?

We understand that the integrity of your research depends on the quality of your materials. Chem14 stands out because we adhere to strict safety and ethics guidelines. We ensure that our packaging is discreet and that our shipping is reliable, whether you are ordering from the USA or Asia. By maintaining a robust online presence and clear communication channels, we aim to be the partner you trust for the long term.

What Are the Documented Side Effects and Toxicity Data in Scientific Literature? ⚠️

Literature reports common adverse effects include drowsiness, cognitive impairment, and ataxia, with severe risks including respiratory depression at high doses.

While Dechloroetizolam is strictly for research, understanding its toxicological profile is essential for laboratory safety. The J Healthcare Initiative notes that common effects observed in non-clinical settings include sedation, reduced motor coordination, and slurred speech . More severe effects, particularly when combined with other depressants, include respiratory depression and unconsciousness . A comprehensive review of designer benzodiazepines published in Pharmaceuticals highlighted that adverse events, including emergency department admissions and DUID (Driving Under the Influence of Drugs) cases, are associated with this class of compounds . These findings emphasize the importance of safe handling, proper lab protocols, and the use of personal protective equipment.

Is Dechloroetizolam Legal in the USA, UK, and Germany? ⚖️

Legal status varies globally; it is a controlled substance in Sweden and Germany, while in the US it may be considered an analogue under the Federal Analogue Act.

The regulatory environment for new psychoactive substances is dynamic. In Germany, Dechloroetizolam is regulated under the New Psychoactive Substances Act (NpSG) as a 1,4-benzodiazepine analogue . In Sweden, it has been classified as a narcotic since 2015 . In the United States, its legal status is complex. It is not explicitly scheduled at the federal level, but it could be treated as a controlled substance analogue under the Federal Analogue Act if intended for human consumption. Researchers in Australia and the UK must consult their local analogue laws, as many fall under “catch-all” legislation designed to control substances with similar structures to prohibited drugs. Always verify the current status with your local regulatory body before ordering.

What Is the Current Scope of Research on Dechloroetizolam? 📚

Current research focuses on analytical detection methods, in vitro metabolism studies, and QSAR modelling to predict receptor binding affinity.

The scientific community continues to study Dechloroetizolam to better understand its place among NPS. Key areas of investigation include:

• Analytical Toxicology: Developing and validating methods like UHPLC-MS/MS to detect Dechloroetizolam and its metabolites in biological matrices .
• Pharmacokinetics: Studies determining the blood-to-plasma ratio, which is crucial for understanding drug distribution. For Dechloroetizolam, this ratio helps predict how much of the compound reaches systemic circulation .
• Metabolite Identification: Research into how the body breaks down this compound, which is essential for forensic confirmation .

Can I buy Dechloroetizolam with credit card?

Yes, Chem14 offers various secure payment options for verified research institutions and individuals. Please proceed to our checkout page for details.

How should I store Dechloroetizolam powder?

Store in a cool, dry, and dark place, ideally between 2-8°C, in an airtight container to maintain stability and prevent degradation.

Is Dechloroetizolam the same as Clonazolam?

No. While both are designer benzodiazepines, Clonazolam is a triazolobenzodiazepine with a different chemical structure and is known to be significantly more potent . Dechloroetizolam is a thienodiazepine analogue of Etizolam.

What is the half-life of Dechloroetizolam?

Specific human pharmacokinetic data is limited, but based on its duration of action (8-10 hours), it is considered an intermediate-acting compound . Formal half-life calculations require controlled studies.

 Do I need a special license to order Dechloroetizolam?

For research use, we require confirmation that you are an adult over 18 and that the substances will be used strictly for analytical or forensic purposes. It is your responsibility to ensure compliance with local laws, which may require institutional approval.

What is the difference between Dechloroetizolam and Etizolam?
Dechloroetizolam lacks the chlorine atom present in etizolam, resulting in roughly half the potency but twice the duration in research observations.

 Is Dechloroetizolam legal to buy for research in the UK?
In the UK it is a Class C substance. We supply it strictly for laboratory research where permitted under current regulations. Always confirm compliance.

What dosage range do researchers typically use?
Laboratory protocols commonly start at light levels of 2-4 mg and adjust based on experimental design. We provide certificates of analysis to support precise work.

 How long do the effects last in controlled studies?
Total duration reaches eight to ten hours with peak activity between three and four hours after administration in standard models.

 Can I buy Dechloroetizolam in Germany or Australia?
Yes, where local laws allow scientific use. Our team verifies shipping eligibility before processing every international order.

What payment methods does Chem14.com accept?
We offer secure options detailed on our payment page. All transactions use encrypted connections.

Why choose Chem14.com over other research chemical vendors?
Our commitment to purity testing, fast global shipping, and transparent documentation makes us the preferred choice for scientists in the UK, USA, Germany, Australia, and Asia.

Key Takeaways for the Discerning Researcher 📝

• Structural Significance: Dechloroetizolam (CAS 40054-73-7) is a crucial analogue for studying the SAR of thienodiazepines .
• Mechanism: It functions as a GABA_A receptor modulator, providing insights into sedative-hypnotic drug design .
• Safety Profile: Documented risks include sedation and cognitive impairment; extreme caution and proper lab safety are non-negotiable .
• Sourcing Integrity: For consistent results, always source from a reliable research chemical supplier like Chem14.
• Regulatory Compliance: The legal status varies by jurisdiction (USA, UK, Germany). Researchers must stay informed on local analogue laws .

At Chem14, we are committed to advancing science by providing the tools researchers need. Whether you are investigating the GABAergic system or developing new analytical methods, we are here to support your work with quality and integrity. For further reading on related topics, check out our blog or our guide on how to find reliable suppliers.

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