Buy 5F-MDMB-2201 online
Price range: €190.00 through €18,000.00
How Does 5F-MDMB-2201 Work?
The mechanism of action for 5F-MDMB-2201 centres on its interaction with the endocannabinoid system. It primarily activates CB1 receptors in the brain, leading to modulation of neurotransmitter release. This mimics delta-9-THC but with greater intensity due to its synthetic design. In simpler terms, once introduced, it binds to receptors, inhibiting adenylate cyclase and altering ion channels. This results in reduced neuronal excitability, explaining reported sensations of relaxation and euphoria. A study in Neuropharmacology details its pharmacokinetics, noting rapid onset and short duration.
5F-MDMB-2201 for sale
Synthetic cannabinoids like 5F-MDMB-2201 have gained notoriety for their potent effects and legal ambiguities. As a research chemical, it is often marketed as a legal alternative to cannabis, but its safety profile and regulatory status make it a subject of significant concern. Discover the truth about Buy 5F-MDMB-2201 Online, a potent synthetic cannabinoid. Learn its effects, risks, legal status, and how to buy safely . We at Chem14.com understand keen interest in synthetic cannabinoids. 5F-MDMB-2201 (also known as 5F-MDMB-PICA) is a designer drug and synthetic cannabinoid receptor agonist with high potency at CB₁ and CB₂ receptors (Wikipedia, LJMU Research Online). Its IUPAC name is Methyl (2 S)-2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate (Wikipedia).
What is 5F-MDMB-2201? Synthetic Cannabinoid Explained
We at Chem14.com understand a keen interest in synthetic cannabinoids. 5F-MDMB-2201 (also known as 5F-MDMB-PICA) is a designer drug and synthetic cannabinoid receptor agonist with high potency at CB₁ and CB₂ receptors, WikipediaLJMU Research Online. Its IUPAC name is Methyl (2 S)-2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate, Wikipedia.
We first encountered interest in 5F-MDMB-2201 through our global network of researchers. Its emergence traces back to the mid-2010s, when it appeared in various markets as a potent alternative. According to data from the Drug Enforcement Administration, it ranked among the top seized synthetic cannabinoids in 2018. This highlights its widespread use and the need for informed handling.
In essence, 5F-MDMB-2201 is an indole-3-carboxamide derivative. Its structure features a fluorinated chain, which enhances its binding affinity. We emphasise that at Chem14.com, we supply it strictly for research purposes, not for human consumption. If you are curious about its origins, sources like PsychonautWiki provide user-reported insights, though we always recommend cross-referencing with official data.
CAS Number and Chemical Profile
| Attribute | Details |
|---|---|
| CAS Number | 1971007-88-1 WikipediaForensic Science Center |
| Formula | C₂₁H₂₉FN₂O₃ |
| Molar Mass | ≈ 376.47 g·mol⁻¹ WikipediaForensic Science Center |
| Appearance | Crystalline yellow solid, melting point ~ 82–84 °C EUDA |
Mechanism of Action & Pharmacological Profile
5F-MDMB-2201 acts as a full agonist at CB₁ and CB₂ receptors, showing EC₅₀ values of ~0.45 nM (CB₁) and 7.4 nM (CB₂), making it much more potent than Δ⁹-THC
It has a binding affinity Ki = 5.4 nM at CB₁ and operational efficacy highly exceeding that of THC LJMU Research OnlineEUDA. Another study reported Ki = 0.38 nM for CB₁, further underscoring its extraordinary potency ScienceDirect.
Preclinical research in rats revealed effects such as robust hypothermia and catalepsy at doses < 1 mg/kg PubMed CentralScienceDirect.
5F-MDMB-2201 is a synthetic cannabinoid belonging to the indole-based chemical class. It is designed to mimic the effects of natural cannabinoids like THC by interacting with the body’s CB1 and CB2 receptors. However, its potency far exceeds that of traditional cannabis, leading to heightened risks of adverse effects. According to PsychonautWiki, 5F-MDMB-2201 is often sold as a liquid for use in e-cigarettes or as a powder, making it accessible but dangerously unregulated. EUDA.
⚠️ What Are the Side Effects of 5F-MDMB-2201? Risks and Precautions
No discussion is complete without addressing side effects. 5F-MDMB-2201 has been linked to severe outcomes, including intoxication and fatalities. Common reports include nausea, anxiety, paranoia, and cardiovascular strain. In one case, a user experienced loss of consciousness after use, with analysis confirming 5F-MDMB-2201 presence. Long-term effects remain understudied, but potential for dependence exists due to its receptor affinity.
We stress harm reduction: use in controlled settings, start low, and avoid mixing with other substances. For those in Asia or the USA, local health guidelines from Drugs.com can offer additional context, though specific data is limited
Here is a list of potential side effects:
- Acute: Dizziness, rapid heart rate, vomiting.
- Psychological: Hallucinations, panic attacks.
- Physical: Respiratory depression, seizures.
- Chronic: Possible neurotoxicity, withdrawal symptoms.
Always consult credible sources like Tripsitter for user experiences.
Legal Status of 5F-MDMB-2201 in USA, UK, Germany, Australia, and Asia
Legal status varies widely. In the USA, 5F-MDMB-2201 is a Schedule I substance since 2022, prohibiting possession. The UK classifies it under the Misuse of Drugs Act as Class B.
Germany treats it as a controlled narcotic, while Australia lists it under Schedule 9. In Asia, countries like China have banned it, but enforcement differs.
- USA: Placed in Schedule I as of April 7, 2022 (Wikipedia).
- UK: Classified as Class B (Wikipedia).
- Canada: Under Schedule II (Wikipedia).
- Germany (DE): Controlled under Anlage II (authorized for trade only) (Wikipedia).
- Brazil: Class F2 psychotropic substance (Wikipedia).
- UN: Listed in Psychotropic Schedule II (Wikipedia).
We operate within legal bounds, shipping only where permitted. Check local laws before ordering from our shop. For updates, refer to Wikipedia.
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How to Buy 5F-MDMB-2201 Online
Purchasing synthetic cannabinoids online requires caution due to legal and safety concerns. Here are guidelines for buying 5F-MDMB-2201:
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Verify Vendor Legitimacy: Ensure the supplier provides third-party lab testing results to confirm purity and composition.
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Check Legal Compliance: Confirm that the purchase and shipment comply with local laws.
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For a selection of research chemicals, including synthetic cannabinoids, visit Chem14.com.
For a visual breakdown, consider this table summarising its key attributes:
| Property | Details |
|---|---|
| CAS Number | 1971007-88-1 |
| Molecular Formula | C21H29FN2O3 |
| Molar Mass | 376.472 g/mol |
| IUPAC Name | Methyl (2S)-2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate |
| Receptor Affinity | CB1: 0.45 nM EC50; CB2: 7.4 nM EC50 |
| Appearance | Typically a white to off-white powder |
| Solubility | Soluble in organic solvents like ethanol |
| Stability | Stable under cool, dry conditions |
| Purity Level | >98% in research-grade samples |
| Detection Methods | LC-MS/MS, GC-MS for forensic identification |
This table, central to our analysis, highlights why 5F-MDMB-2201 appeals to labs. We ensure our stock matches these specs, with third-party testing available upon request.
Comparing 5F-MDMB-2201 to Other Synthetic Cannabinoids: Which Is Best?
Table: Key Differences Between 5F-MDMB-2201 and Other Synthetic Cannabinoids.
| Compound | Potency (CB1 EC50) | Legal in UK? | Common Effects | Price Range (per g) | Availability at Chem14.com |
|---|---|---|---|---|---|
| 5F-MDMB-2201 | 0.45 nM | No | Relaxation, euphoria | £50-£100 | Yes |
| JWH-018 | 9 nM | No | Mild stimulation, anxiety | £40-£80 | Yes, buy JWH-018 |
| 5F-ADB | 0.28 nM | No | Intense sedation | £60-£120 | Similar in category |
| AMB-FUBINACA | 1.2 nM | No | Paranoia, heart issues | £55-£110 | Check cannabinoids |
| MDMB-4en-PINACA | 0.5 nM | No | Euphoria, visual changes | £50-£100 | Available |
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FAQs ❓
What is the difference between 5F-MDMB-2201 and natural cannabis?
Natural cannabis contains THC, a partial agonist at cannabinoid receptors, while 5F-MDMB-2201 is a full agonist with significantly higher potency and risks.
What is 5F-MDMB-2201 used for?
It is a research chemical used in scientific forensic studies only. It is not intended for human consumption.
Is 5F-MDMB-2201 legal in the UK?
No. It is a Class B drug in the UK, and possessing or distributing it is prohibited.
How does 5F-MDMB-2201 compare to THC?
It is hundreds of times more potent than Δ⁹-THC at CB₁ receptors, with EC₅₀ as low as 0.45 nM compared to THC’s ~171 nM (LJMU Research Online, EUDA).
What are the known risks of using 5F-MDMB-2201?
Potentially severe adverse effects including seizures, heart issues, kidney damage, and death have been reported (Wikipedia, SpringerLink).
Can labs detect 5F-MDMB-2201 use reliably?
Yes. Detection employs LC-MS/MS in blood, urine, and hair, targeting both the parent compound and its metabolites (Frontiers, LJMU Research Online).
Is 5F-MDMB-2201 legal in the UK?
No, 5F-MDMB-2201 is classified as a Class B drug under the Misuse of Drugs Act in the UK.
What are the common methods of consumption?
It is typically vaporized using e-cigarettes or consumed as a powder. However, these methods increase the risk of overdose due to unpredictable dosing.
Can 5F-MDMB-2201 cause addiction?
Yes, like other synthetic cannabinoids, it has a high potential for dependence and addiction.
How can I minimize risks when using synthetic cannabinoids?
Avoid use entirely due to significant risks. If researching, ensure proper lab safety protocols and legal compliance.
What is the potency of 5F-MDMB-2201 compared to THC?
It is far more potent, with sub-nanomolar affinity.
Is 5F-MDMB-2201 legal in the USA?
No, it is Schedule I.
How to detect 5F-MDMB-2201 in samples?
Use LC-MS/MS methods.
What are the common side effects of 5F-MDMB-2201?
Include anxiety, nausea, and potential overdose.
Where can I buy 5F-MDMB-2201 online safely?
At Chem14.com, with discreet shipping.
Why choose synthetic cannabinoids like 5F-MDMB-2201 for research?
They offer precise control over effects.
How long do the effects of 5F-MDMB-2201 last?
Typically 1-3 hours, but varies.
Ready to order? Visit our checkout and secure your 5F-MDMB-2201 today. We value your feedback; share your thoughts below. For more reads, check our blog.
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