Buy 4-AcO-DMT Online
We provide high purity 4-AcO-DMT (O-Acetylpsilocin) for laboratory and research purposes. Our synthetic tryptamine undergoes rigorous testing to ensure superior quality. Available in powder and fumarate forms, this compound is ideal for studying the effects of prodrug psychedelics on the central nervous system. We ship discreetly to the USA, UK, Germany, and worldwide. Buy 4-AcO-DMT online today to advance your scientific inquiries with guaranteed satisfaction.
What Is 4-AcO-DMT? Definition, CAS Number & Chemical Profile
4-AcO-DMT (Psilacetin, O-Acetylpsilocin) is a synthetic tryptamine and a prodrug of psilocin, the active metabolite of psilocybin (the compound found in “magic mushrooms”). It was first synthesized in 1963 by Albert Hofmann and Franz Troxler and later improved by David E. Nichols in 1999 as a more economical alternative to psilocybin for research purposes.
- CAS Number: 92292-84-7 (freebase), 2748484-99-1 (hydrochloride), 1217230-42-6 (fumarate)
- Chemical Structure: Features an acetoxy group attached to the tryptamine backbone, differentiating it from psilocybin’s phosphate ester.
- Mechanism of Action: Acts as a non-selective serotonin receptor agonist, primarily targeting the 5-HT2A receptor, which mediates its psychedelic effects.
Chemical and Pharmacological Profile of O-Acetylpsilocin
O-Acetylpsilocin belongs to the tryptamine family, characterized by a core indole ring structure. The chemical formula is C14H18N2O2, and it features a CAS number of 92260-49-0. This specific identifier helps researchers verify the exact compound they are analysing.
In terms of pharmacology, 4-AcO-DMT functions primarily as a serotonergic psychedelic. It interacts with the 5-HT2A receptor subtype. This interaction is largely responsible for the psychedelic effects observed in clinical and observational settings. Unlike many other stimulants or depressants, this compound does not typically affect dopamine or norepinephrine systems to the same degree.
We ensure that every batch we supply meets strict analytical standards. Researchers can review the chemical profile on databases like DrugBank to cross-reference structural data. Understanding the pharmacokinetics, such as the onset time and duration of effects, is vital for any legitimate study involving this material.
Chemical Summary Table
| Property | Detail |
|---|---|
| IUPAC Name | 3-(2-acetyloxyethyl)-1H-indol-4-yl dimethylamine |
| CAS Number | 92260-49-0 |
| Chemical Formula | C14H18N2O2 |
| Molar Mass | 246.31 g/mol |
| Form | White powder (HCl or Fumarate) |
| Class | Tryptamine / Psychedelic |
| Solubility | Soluble in water and ethanol |
Mechanism of Action: How Does 4-AcO-DMT Work?
4-AcO-DMT works by acting as a prodrug for psilocin. Once ingested, enzymes in the body remove the acetyl group, converting it into psilocin.
Psilocin then binds to and activates serotonin receptors in the brain, specifically the 5-HT2A receptor. This receptor is crucial for regulating mood, cognition, and perception. By agonizing this receptor, the substance alters the brain’s default mode network, leading to changes in thought patterns and visual processing.
According to information found on Drugs.com, similar compounds are used to study neural pathways. Understanding this mechanism is why many scientists look to buy 4-AcO-DMT online. It provides a consistent and reproducible way to stimulate these receptors without the variability of organic mushrooms.
The specificity of 4-AcO-DMT for the 5-HT2A receptor makes it a key candidate for researching treatments for depression and anxiety disorders, although clinical trials are still ongoing.
How Does 4-AcO-DMT Work?
4-AcO-DMT is rapidly metabolized into psilocin by esterase enzymes in the body, with over 99.9% conversion within 5 minutes in human plasma. This makes it functionally identical to psilocybin in terms of psychoactive effects, but with a faster onset and potentially smoother experience.
Comparison to Psilocybin and DMT
| Feature | 4-AcO-DMT | Psilocybin | DMT |
|---|---|---|---|
| Onset | 20-40 minutes | 30-60 minutes | Seconds (smoked) |
| Duration | 4-8 hours | 4-6 hours | 5-30 minutes |
| Nausea | Reduced | Common | Rare |
| Visuals | Bright, geometric | Earthy, organic | Intense, fractal |
| Legal Status | Gray area | Schedule I (USA) | Schedule I (USA) |
Source: PsychonautWiki, ACS Lab
Dosage Guide: How Much 4-AcO-DMT Should You Take?
Dosage ranges for 4-AcO-DMT vary by experience level and route of administration:
| Experience Level | Oral Dose (mg) | Insufflated Dose (mg) | Effects |
|---|---|---|---|
| Threshold | 2-5 | 1-3 | Mild sensory enhancement |
| Light | 5-10 | 3-8 | Enhanced colors, introspection |
| Common | 10-20 | 8-15 | Full psychedelic experience |
| Strong | 20-30 | 15-25 | Intense visuals, ego loss |
| Heavy | 30+ | 25+ | Overwhelming, mystical |
Note: Insufflation (snorting) results in a faster, more intense onset but shorter duration.
Effects of 4-AcO-DMT:
While our products are for in vitro research, understanding the potential biological effects is necessary for handling them safely. Literature from Tripsitter suggests that physiological effects can include mydriasis (pupil dilation), increased heart rate, and nausea.
Psychological effects may include anxiety, confusion, or ego dissolution if the substance is mishandled. In a laboratory setting, researchers must wear appropriate personal protective equipment (PPE). This includes gloves, goggles, and lab coats to prevent accidental exposure.
Physical and Cognitive Effects
- Visuals: Bright, geometric patterns, enhanced colors, and closed-eye imagery.
- Emotional: Euphoria, introspection, empathy, and ego dissolution.
- Body Load: Generally less nausea than psilocybin mushrooms, with a smoother come-up.
- Duration: Effects peak at 2-3 hours and last 4-8 hours.
User Experiences
“4-AcO-DMT felt like a cleaner, more controlled version of mushrooms. The visuals were brighter, and the body load was almost nonexistent.” — PsychonautWiki
Side Effects and Safety Considerations
Common Side Effects
- Psychological: Anxiety, paranoia, or low mood (especially in high doses or unfavorable settings).
- Physical: Mild nausea, increased heart rate, or temporary cognitive impairment.
Who Should Avoid 4-AcO-DMT?
- Individuals with a history of schizophrenia, severe anxiety, or cardiovascular issues.
- Those on MAOIs, lithium, or tramadol (risk of dangerous interactions).
Safety Tip: Always start with a low dose and use a trip sitter for harm reduction.
Legal Status of 4-AcO-DMT
Legal Status by Country
| Country/Region | Legal Status |
|---|---|
| USA | Gray area: Not explicitly scheduled, but may fall under the Federal Analogue Act as a psilocin analog. |
| UK | Class A (illegal to possess, produce, or supply) under the Misuse of Drugs Act. |
| Germany | Controlled substance (Anlage I) under the NpSG. |
| Australia | Schedule 9 (prohibited substance). |
| Asia | Varies: Generally illegal in most countries (e.g., Japan, China). |
Note: Laws are subject to change. Always check local regulations before purchasing or using 4-AcO-DMT.
Research and Therapeutic Potential
Why Are Researchers Interested in 4-AcO-DMT?
- Cost-Effective Alternative: Easier and cheaper to synthesize than psilocybin, making it ideal for pharmacological research.
- Therapeutic Potential: Early studies suggest it may help with depression, PTSD, and anxiety, similar to psilocybin.
- Reduced Side Effects: Users report less nausea and body load compared to magic mushrooms.
Where to Buy 4-AcO-DMT Online Safely in the UK and USA
Finding a reliable supplier is often the most challenging part of research. At Chem14, we simplify this process. We offer 4-AcO-DMT for sale with a focus on safety, legality, and discretion.
We serve a diverse client base across the United Kingdom, United States of America, Germany, Australia, and Asia. Our platform adheres to strict safety guidelines. We ensure that all transactions are secure and that packaging is discreet to maintain privacy.
When you buy psychedelic research chemicals for sale from us, you receive a Certificate of Analysis. This document verifies the purity of the compound, ensuring that your research results are accurate and reproducible. We advise all customers to review our research ethics and safety guidelines before purchasing.
Legal Status of 4-AcO-DMT in Europe and Australia
The legal landscape for synthetic tryptamines varies significantly by jurisdiction. In the United Kingdom, 4-AcO-DMT is a Class A drug under the Misuse of Drugs Act 1971. This makes it illegal to produce, supply, or import for human consumption.
In the United States, the situation is complex. While not explicitly scheduled at the federal level, it may be considered an analogue of psilocin under the Federal Analogue Act, depending on its intended use. This makes it risky to possess without proper licensing for research.
In Germany and other parts of Europe, it often falls under controlled substance legislation, specifically the NpSG (New Psychoactive Substances Act). Australia classifies it as a Schedule 9 prohibited substance.
We strongly recommend checking local laws before you buy 4-AcO-DMT online. Our products are strictly for laboratory and research use only and are not intended for human consumption. You can read more about the legal status on Wikipedia or through PsychonautWiki.
Potential Side Effects and Safety Considerations
While our products are for in vitro research, understanding the potential biological effects is necessary for handling them safely. Literature from Tripsitter suggests that physiological effects can include mydriasis (pupil dilation), increased heart rate, and nausea.
Psychological effects may include anxiety, confusion, or ego dissolution if the substance is mishandled. In a laboratory setting, researchers must wear appropriate personal protective equipment (PPE). This includes gloves, goggles, and lab coats to prevent accidental exposure.
We prioritize safety at Chem14. Please consult our FAQ section for detailed handling instructions. We advise researchers to keep a neutralising agent nearby and to work in a fume hood when handling powders.
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Choosing the right vendor impacts the quality of your research. We distinguish ourselves through product purity and customer service.
- Verified Purity: We test all batches using GC-MS and HPLC techniques.
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If you are looking to buy tryptamines for sale, our catalogue includes a wide range of compounds. From 4-AcO-MET to 4-AcO-MIPT, we stock the latest substances needed for modern science.
Research Applications and Uses
The primary application of 4-AcO-DMT is in forensic toxicology and neuroscience. Researchers use it to study receptor binding affinities. It is also used to develop detection methods for novel psychoactive substances in biological samples.
Some academic institutions study its potential as a therapeutic agent. The mechanism involving the 5-HT2A receptor is a target for developing new antidepressants. By studying how this compound alters neural plasticity, scientists hope to understand the biological basis of mood disorders.
We supply to universities, private laboratories, and research institutes. If your institution requires a specific formulation, please contact us. We also offer related products like SGT-78 and 5F-MDA-19 for broader research needs.
Is 4-AcO-DMT the same as psilocybin?
No, but it metabolizes into psilocin, the same active compound as psilocybin. Effects are very similar, though some users report 4-AcO-DMT is smoother and more visual.
Can you microdose 4-AcO-DMT?
Yes. A typical microdose is 1-5 mg, taken every few days. Users report enhanced creativity, focus, and mood without full psychedelic effects.
Where can I buy 4-AcO-DMT online?
You can order 4-AcO-DMT for sale at Chem14.com, a trusted supplier of high-purity research chemicals with worldwide shipping.
Is 4-AcO-DMT legal in the USA?
It exists in a legal gray area. While not explicitly scheduled, it may be considered an analog of psilocin under the Federal Analogue Act.
How long does 4-AcO-DMT last?
Effects typically last 4-8 hours, with the peak occurring at 2-3 hours after ingestion.
Is 4-AcO-DMT the same as magic mushrooms?
They are not the same chemically, but they produce similar effects. 4-AcO-DMT is a synthetic prodrug that converts to psilocin, the same active metabolite found in psilocybin mushrooms.
Where can I buy 4-AcO-DMT online?
You can purchase high quality 4-AcO-DMT directly from Chem14.com. We ensure secure shipping and laboratory grade purity for researchers.
What is the recommended dosage for research?
There is no safe dosage for human consumption. For laboratory analysis, researchers typically handle micrograms to milligrams depending on the assay sensitivity. Always follow safety protocols.
Is 4-AcO-DMT legal in the United Kingdom?
No, in the UK it is classified as a Class A drug. It is illegal to possess or supply it for personal use. However, licensed laboratories may obtain it for specific analytical purposes under strict regulations.
How should I store 4-AcO-DMT?
Store the compound in a cool, dry place away from direct sunlight. Ideally, keep it in a sealed container at -20°C for long term stability to prevent degradation from moisture and heat.
📌 Key Takeaways
- 4-AcO-DMT is a synthetic prodrug of psilocin, offering a smoother, more visual experience than psilocybin mushrooms.
- Dosage ranges from 5-30 mg (oral), with effects lasting 4-8 hours.
- Legal status varies: Check local laws before purchasing.
- Potential therapeutic benefits for mental health, but more research is needed.
- Always prioritize safety: Start low, go slow, and use a trip sitter.
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References:
- Wikipedia: 4-AcO-DMT
- PsychonautWiki: 4-AcO-DMT
- Recovered: Risks and Benefits of 4-AcO-DMT
- ACS Lab: 4-AcO-DMT Guide
- Cayman Chem: 4-AcO-DMT (Hydrochloride))
- Recovered: Dosage and Safety
- The Hemp Doctor: Dosage Guide
- Third Wave: Microdosing 4-AcO-DMT
- Psychedelic Science Review: 4-AcO-DMT vs. Psilocybin
- Herb: Is 4-AcO-DMT Legal?
- LegalClarity: 4-AcO-DMT Legal Status
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