Buy Proscaline online
Proscaline is a psychedelic phenethylamine and a potent analogue of mescaline. Known for its clear-headed, introspective, and long-lasting effects (8-12 hours), it is strictly for research use and sold in high purity at Chem14.com. At Chem14.com, we offer high-purity Proscaline for research purposes only, with secure worldwide shipping to locations including the United Kingdom, United States, Germany, Australia, and parts of Asia. Buy Proscaline online from a trusted vendor at Chem14.com. This compound, also called 4-propoxy-3,5-dimethoxyphenethylamine, provides researchers with a potent tool for studying serotonergic psychedelics.
What is Proscaline?
Proscaline is a synthetic psychedelic phenethylamine and mescaline analogue, active orally at 15-60 mg, producing visual and introspective effects lasting 8-12 hours.
Proscaline stands out in the family of research chemicals due to its structural similarity to mescaline but with enhanced potency. Alexander Shulgin documented it in PiHKAL, noting effects from doses of 30-60 mg. We at Chem14.com prioritise quality and safety in our psychedelics for sale category.
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What is the Chemical and Pharmacological Profile of Proscaline?
Proscaline, chemically known as 4-propoxy-3,5-dimethoxyphenethylamine (or 2-(3,5-dimethoxy-4-propoxyphenyl)ethanamine), has the molecular formula C13H21NO3 and a molar mass of 239.315 g/mol. Its CAS number is 39201-78-0 (freebase), with the hydrochloride salt at 61367-69-9.
This compound belongs to the scaline family (4-substituted 3,5-dimethoxyphenethylamines). It acts primarily as a serotonin receptor agonist, with strong affinity for 5-HT2C receptors and notable activity at 5-HT2A receptors, which drive its psychedelic properties. Compared to mescaline, Proscaline shows roughly 5-7 times greater potency by weight.
When you decide to buy Proscaline online, verifying the chemical identifiers is non-negotiable.
- IUPAC Name: 2-(3,5-dimethoxy-4-propoxyphenyl)ethanamine
- CAS Number: 39201-78-0 (freebase) / 61367-69-9 (hydrochloride salt)
- Molecular Formula: C₁₃H₂₁NO₃
- Molecular Weight: 239.31 g/mol (freebase)
- Melting Point: 170-172 °C (hydrochloride salt)
Researchers value it for exploring altered states, sensory enhancement, and serotonin system interactions. View our full range of tryptamines for sale and psychedelics sections.
How Does Proscaline Work? Mechanism of Action Explained
Proscaline functions as an agonist at serotonin 5-HT2 receptors, especially 5-HT2A, 5-HT2B, and 5-HT2C. Activation of 5-HT2A receptors underlies classic psychedelic experiences, including perceptual changes and introspection.
It produces the head-twitch response in animal models, a marker of hallucinogenic potential. Unlike some stimulants, its profile leans more toward sensory sharpening and relaxation than intense stimulation. This makes it a useful analog for comparative studies on phenethylamine psychedelics.
For more on related compounds, check our dissociative or stimulants categories.
What Are the Typical Effects of Proscaline?
Users and researchers report effects similar to mescaline but more efficient due to lower dosing.
Positive effects often include:
- Euphoria and empathy
- Enhanced colours and visual patterns (open and closed-eye)
- Sharpened senses and tactile enhancement
- Insightful thinking and relaxation
- Mild mental stimulation
Neutral effects may feature time distortion, pupil dilation, and appetite suppression.
Potential challenges involve restlessness, sweating, or chills at higher doses.
Effects typically onset in 30-60 minutes, peak over several hours, and last 8-12 hours total, with after-effects up to 5 hours.
What Dosage Should Researchers Consider for Proscaline?
Understanding the dose-response curve is critical for safety. Based on data from PsychonautWiki and Shulgin’s original notes, here is the breakdown for oral administration.
| Parameter | Details |
|---|---|
| Threshold | 10 mg |
| Light Dose | 15 – 30 mg |
| Common Dose | 30 – 40 mg |
| Strong Dose | 40 – 60 mg |
| Heavy Dose | 60 mg + |
| Onset | 30 – 60 minutes |
| Duration | 8 – 12 hours |
| After Effects | 3 – 5 hours |
Reported Effects
Users on platforms like Erowid and PsychonautWiki describe Proscaline as a “gentle” psychedelic relative to substances like LSD or Psilocybin.
- Positive Effects: Enhanced mood, mild stimulation, vivid closed-eye visuals, increased introspection, and appreciation of music .
- Neutral Effects: Time distortion, enhanced tactile sensation, pupil dilation.
- Adverse Effects: At higher doses, users report nausea, anxiety, and over-stimulation. It is noted for lacking the deep ego dissolution of mescaline, making it more functional in lower doses .
What Side Effects Are Associated with Proscaline?
Limited data exists, but potential side effects mirror other phenethylamines:
- Nausea (less common than with mescaline)
- Increased heart rate or blood pressure
- Anxiety or restlessness
- Pupil dilation
- Sweating or chills
No severe toxicity is widely reported in available literature, but long-term effects remain understudied. Use responsibly in research contexts only.
Proscaline vs. Other Psychedelic Phenethylamines
To help contextualize Proscaline within the broader family, we have compared it to its closest relatives.
| Compound | Potency | Duration | Subjective Quality | Legal Status (UK) |
|---|---|---|---|---|
| Proscaline | High (30-60mg) | 8-12 hrs | Clear-headed, mild visuals, stimulating | Class A |
| Mescaline | Low (200-400mg) | 10-14 hrs | Deep, emotional, natural, high body load | Class A |
| Escaline | Moderate (40-80mg) | 8-10 hrs | Luminous, sensual, warmer than Proscaline | Class A |
| Methallylescaline | Moderate (40-80mg) | 6-10 hrs | Similar to Escaline, slightly shorter duration | Class A |
| 2C-B | High (15-25mg) | 4-6 hrs | Sharp visuals, tactile enhancement, shorter | Class A |
For researchers looking to explore this category, we also offer a range of high-quality psychedelic research chemicals for sale including Methallylescaline and other essential compounds.
What is the Legal Status of Proscaline in Key Countries?
Proscaline lacks explicit scheduling in many places but falls under analogue laws or psychoactive substance acts.
- United States: Not federally scheduled, but may qualify as a controlled substance analogue under the Federal Analogue Act if intended for human consumption.
- United Kingdom: Class A controlled substance.
- Germany: Not explicitly listed, but new psychoactive substances face restrictions.
- Australia: Schedule 9 (prohibited for most uses except approved research).
- Asia (varies): Often unregulated or restricted under general drug laws.
At Chem14.com, we sell strictly for research, not human use. Review our legal disclaimer and research ethics & safety guidelines.
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Where to Buy Proscaline Online? Best Vendors in the USA, UK, and Australia
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Why Choose Chem14 for Proscaline?
- Lab-Tested Purity: Our Proscaline powder comes with Certificates of Analysis (COA) to verify the structure and eliminate uncertainty. We typically offer ≥98% purity.
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Where to Buy Proscaline Online in USA, UK, Germany, Australia?
Chem14.com serves as a reliable source for Proscaline for sale. We provide discreet shipping to the USA, UK (London included), Germany, Australia, and select Asian regions. Explore our shop or psychedelic research chemicals for sale page.
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What is the CAS number for Proscaline?
The CAS number for the freebase is 39201-78-0. If you are looking for the hydrochloride salt form (often used for research due to stability), the CAS is 61367-69-9 .
Is Proscaline legal in the United States?
It is not a scheduled substance federally. However, it is an analogue of mescaline. Under the Federal Analog Act, if it is sold for human consumption, it is treated as a Schedule I substance. We sell Proscaline strictly for analytical and research purposes only, not for human consumption.
How long does a Proscaline trip last?
Based on anecdotal reports from PsychonautWiki and user forums, the experience is lengthy. The main effects typically last 8 to 12 hours, with residual after-effects lasting a few hours longer .
How does Proscaline compare to Mescaline?
Proscaline is significantly more potent than mescaline (about 5x). Users report that mescaline is more visual and emotionally profound, while Proscaline is often described as more stimulating and clear-headed, with less “body load” .
Can I buy Proscaline powder for research in the UK?
Given that Proscaline is a Class A drug in the UK, we strongly advise against it. We recommend all customers ensure full compliance with their local laws, such as the Psychoactive Substances Act 2016 in the UK, which bans any psychoactive substance for human consumption.
What are the side effects of Proscaline?
The toxicity profile is not well-studied. However, common side effects associated with this class include nausea, pupil dilation, mild anxiety, and vasoconstriction. At higher doses (60mg+), the risk of confusion and physical discomfort increases .
Is Proscaline the same as 3C-P?
No. While related, they are different. 3C-P (3C-Proscaline) is the alpha-methylated version, meaning it has an amphetamine backbone. This makes 3C-P a substituted amphetamine and a psychedelic, whereas Proscaline is a simpler phenethylamine. 3C-P is generally more potent and stimulating .
Where can I find Proscaline for sale in Germany?
While we ship globally, researchers in Germany must be aware of the NpSG regulations. We recommend contacting us to ensure compliance before ordering.
What is Proscaline?
Proscaline is a psychedelic phenethylamine related to mescaline, active at lower doses and producing similar visual and introspective effects.
How long do Proscaline effects last?
Effects typically last 8-12 hours, with onset in 30-60 minutes and after-effects for 3-5 hours.
Is Proscaline legal in the UK?
Proscaline is classified as a Class A substance in the United Kingdom, making possession and supply illegal.
What is the recommended starting dose for Proscaline research?
Light doses range from 15-30 mg orally, though individual response varies; always verify with lab protocols.
Where can I buy Proscaline online safely?
Chem14.com offers high-quality Proscaline for research, with secure shipping to the USA, UK, Germany, Australia, and more.
How does Proscaline compare to mescaline?
Proscaline is roughly 5-7 times more potent, requiring lower doses for comparable psychedelic effects.
Can Proscaline cause visual hallucinations?
Yes, it often produces enhanced colours, patterns, and open/closed-eye visuals similar to other classic psychedelics.
Is Proscaline addictive?
No evidence suggests habit-forming potential; tolerance builds quickly but dissipates after days.
What are common side effects of Proscaline?
Possible effects include restlessness, pupil dilation, sweating, or mild nausea at higher doses.
How to order Proscaline from Chem14.com?
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